178 papers
This study utilizes a unique multimodal dataset to demonstrate that while affective and functional disturbances emerge in early psychosis stages, cognitive and neuroanatomical abnormalities characterize more advanced phases, yet significant overlapping phenotypes across risk groups underscore the need for personalized care beyond traditional diagnostic boundaries.
This randomized controlled trial demonstrates that long-term use of the video game therapeutic Meliora for major depressive disorder does not increase gaming-related problems, even with high engagement or immersion, supporting the safety of video games as a medium for digital therapeutics.
This longitudinal study of youth accessing early intervention services reveals that longer baseline sleep duration, measured via actigraphy, significantly predicts a higher risk and faster progression to full-threshold bipolar or psychotic disorders, suggesting excessive sleep may serve as an early objective marker for severe mental illness vulnerability.
This preliminary case-control study found no significant difference in adropin levels between patients with schizophrenia and healthy volunteers, though it identified several notable correlations between adropin, anthropometric, and psychological factors that warrant further investigation.
This paper presents a protocol and literature review for the "Impact Log," a novel, lived-experience-led tool and framework designed to systematically record, evaluate, and enhance the impact of co-production across all stages of the Brain and Genomics Hub's multidisciplinary research on severe mental illness.
This study demonstrates that trial-by-trial fluctuations in hippocampal theta oscillations selectively modulate the rate of evidence accumulation during mnemonic decision-making, with distinct hemispheric associations suggesting a role in partial-match sensitivity despite the lack of statistically credible differences between the left and right hemispheres.
This retrospective analysis of 53 patients failed to replicate the previously reported correlation between baseline corrected QT interval and VNS treatment response in difficult-to-treat depression, but instead identified lower absolute neutrophil count, lower BMI, younger age, and higher LDL levels as potential baseline predictors of improvement.
This systematic review and meta-analysis of 68 studies involving over 82,000 participants reveals that posttraumatic stress disorder affects approximately 43% of conflict-affected adults in Sub-Saharan Africa, with significantly higher rates among refugees and strong associations with female sex, comorbid depression, and cumulative trauma exposure.
This study demonstrates that psychosis diagnosis modifies the relationship between default mode network connectivity and tobacco use, specifically revealing that higher connectivity is associated with increased tobacco use in individuals with psychosis, suggesting that modulating these neural circuits could serve as a targeted treatment for tobacco dependence in this population.
This mixed-methods study demonstrates that a brief, digital imagery-competing task intervention is an acceptable and effective treatment for reducing intrusive memories in healthcare staff experiencing work-related trauma, with benefits sustained over 24 weeks despite initial skepticism and requiring minimal ongoing usage after an initial guided session.
By applying Genomic Structural Equation Modeling to separate childhood-onset and treatment-resistant major depression from general major depression, this study reveals that these subtypes possess distinct genetic architectures and biological pathways more akin to separate disorders, suggesting that stratifying depression by these clinically relevant subtypes is crucial for advancing biological discovery and understanding etiology.
This real-world study demonstrates that a risk calculator-informed stepped care model implemented at the Yale PRIME Clinic is feasible and associated with significant, sustained improvements in a broad range of symptoms for young people at clinical high risk for psychosis.
This study validates and extends the COBY risk calculator to accurately predict both threshold and subthreshold mood recurrences in young people with bipolar disorder, demonstrating good discrimination and improved calibration for potential clinical implementation in personalized monitoring and early intervention.
This study demonstrates that passive smartphone-based mobile sensing provides a valid, scalable, and robust alternative to actigraphy for monitoring sleep timing and duration in adolescents and young adults with bipolar disorder.
Using data from the MindCrowd cohort, this study demonstrates that performance-based assessments of cognition are significantly less susceptible to demographic influences such as race, ethnicity, and education compared to traditional verbal memory tests, suggesting they offer a more equitable approach for evaluating cognitive function in diverse populations.
The Meta-Care Trial is a randomized controlled study protocol designed to evaluate the effectiveness of a pragmatic, individualized, evidence-based metabolic care clinic in achieving significant weight loss and improving cardiometabolic health among patients with severe mental illness in Denmark.
This naturalistic study of 88 adults in Oregon's state-regulated psilocybin program found that sessions resulted in significant, clinically meaningful improvements in depression, anxiety, and well-being at 30 days post-session, with no persistent adverse events reported.
This study demonstrates that prenatal SSRI exposure alters mitochondrial function and elevates specific lysophosphatidylcholines in human neural cells and infant cord blood, with these metabolite levels correlating dose-dependently with early autism and ADHD symptoms.
This international, multi-centre study demonstrates that pretrained multilingual embeddings applied to speech recordings from 453 patients can accurately predict eight relapse-related PANSS symptoms in schizophrenia spectrum disorders with low error rates, offering a scalable, low-burden tool for objective symptom monitoring across diverse languages.
Using Dynamic Time Warping analysis on a 13-year longitudinal dataset, this study reveals that suicidal ideation is a dynamic phenomenon that most strongly co-fluctuates with specific affective depressive symptoms, as well as acute fear and persistent worry, suggesting that personalized prevention strategies should target these specific temporal symptom patterns.